MERCK 100864.2500 Ethyl acetate suitable for use as excipient EMPROVE® CAS No.141-78-6 - Laboratuvar Malzemeleri ve Cihazları Tedarikçisi

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SD.M.100864.2500

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MERCK 100864.2500 Ethyl acetate suitable for use as excipient EMPROVE® CAS No.141-78-6

Description
Catalogue Number	100864
Synonyms	Ethyl ethanoate, Acetic ester, Ethyl ester
Description	Ethyl acetate

Physicochemical Information
Boiling point	77 °C (1013 hPa)
Density	0.90 g/cm3 (20 °C)
Explosion limit	2.1 - 11.5 %(V)
Flash point	-4 °C
Ignition temperature	460 °C
Melting Point	-83 °C
Vapor pressure	97 hPa (20 °C)
Solubility	85.3 g/l

Toxicological Information
LD 50 oral	LD50 Rat 5620 mg/kg
LD 50 dermal	LD50 Rabbit > 18000 mg/kg

Safety Information according to GHS
Hazard Pictogram(s)
Hazard Statement(s)	H225: Highly flammable liquid and vapour.H319: Causes serious eye irritation.H336: May cause drowsiness or dizziness.EUH066: Repeated exposure may cause skin dryness or cracking.
Precautionary Statement(s)	P210: Keep away from heat, hot surfaces, sparks, open flames and other ignition sources. No smoking.P233: Keep container tightly closed.P240: Ground and bond container and receiving equipment.P241: Use explosion-proof electrical/ ventilating/ lighting equipment.P242: Use non-sparking tools.P305 + P351 + P338: IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.P403 + P233: Store in a well-ventilated place. Keep container tightly closed.
Signal Word	Danger
RTECS	AH5425000
Storage class	3 Flammable liquids
WGK	WGK 1 slightly hazardous to water
Disposal	1Strongly contaminated halogen-free organic solvents: container A.

Safety Information
Categories of danger	highly flammable, irritant

Storage and Shipping Information
Storage	Store at +2°C to +30°C.

Transport Information
Declaration (railroad and road) ADR, RID	UN 1173, 3, II
Declaration (transport by air) IATA-DGR	UN 1173, 3, II
Declaration (transport by sea) IMDG-Code	UN 1173, 3, II

Specifications
Assay (GC)	98.0 - 102.0 %
Identity (IR)	conforms
Appearance of solution	conforms
Acidity (Ph Eur, BP)	conforms
Acidity (NF)	conforms
Density (d 20 °C/20 °C)	0.898 - 0.902
Density (d 25 °C/25 °C)	0.894 - 0.898
Refractive index (n 20/D)	1.370 - 1.373
Cu (Copper)*	≤ 0.05 ppm
Ru (Ruthenium)*	≤ 0.05 ppm
Acetaldehyde (GC)	≤ 0.1 %
1-Ethoxy-2-methylpropane (GC)	≤ 0.1 %
Methyl compounds (GC)	≤ 0.1 %
Other impurities (GC)	≤ 0.3 %
Related substances (GC)	≤ 0.2 %
Residual solvents class 3 (ICH Q3C)	< 0.5
Readily carbonizable substances	conforms
Evaporation residue	≤ 0.0030 %
Water	≤ 0.10 %
Elemental impurity specifications have been set considering ICH Q3D (Guideline for Elemental Impurities).Class 1-3 elements are not likely to be present above the ICH Q3D option 1 limit, unless specified and indicated (*).Conforms to Ph Eur, BP, NF.